A 3-D framework for arterial growth and remodeling in response to altered hemodynamics

Karšaj, Igor and Sorić, Jurica and Humphrey, Jay D. (2010) A 3-D framework for arterial growth and remodeling in response to altered hemodynamics. = A 3-D framework for arterial growth and remodeling in response to altered hemodynamics. International Journal of Engineering Science, 48 (11). pp. 1357-1372. ISSN 0020-7225. Vrsta rada: ["eprint_fieldopt_article_type_article" not defined]. Kvartili JCR: Q2 (2010). Točan broj autora: 3.

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Abstract

We present a three-dimensional mathematical framework for modeling the evolving geometry, structure, and mechanical properties of a representative straight cylindrical artery subjected to changes in mean blood pressure and flow. We show that numerical predictions recover prior findings from a validated two-dimensional framework, but extend those findings by allowing effects of transmural gradients in wall constituents and vasoactive molecules to be simulated directly. Of particular note, we show that the predicted evolution of the residual stress related opening angle in response to an abrupt, sustained increase in blood pressure is qualitatively similar to measured changes when one accounts for a nonlinear transmural distribution of pre-stretched elastin. We submit that continuum-based constrained mixture models of arterial adaptation hold significant promise for deepening our basic understanding of arterial mechanobiology and thus for designing improved clinical interventions to treat many different types of arterial disease and injury. © 2010 Elsevier Ltd. All rights reserved.

Item Type:	Article (["eprint_fieldopt_article_type_article" not defined])
Keywords (Croatian):	Adaptation; Arterial disease; Arterial growth; Constrained mixture model; Finite elasticity; Hypertension; Mathematical frameworks; Mechano-biology; Mixture model; Numerical predictions; Opening angle; Blood; Blood pressure; Elasticity; Mechanical properties; Mixtures; Three dimensional
Subjects:	TECHNICAL SCIENCE > Mechanical Engineering
Divisions:	200 Department of Engineering Mechanics > 210 Chair of Mechanics and Strength of Materials
Indexed in Web of Science:	Yes
Indexed in Current Contents:	Yes
Quartiles:	Q2 (2010)
Date Deposited:	15 Apr 2015 09:23
Last Modified:	28 Nov 2016 14:43
URI:	http://repozitorij.fsb.hr/id/eprint/3647

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