Effects of bioreactive acrolein from automotive exhaust gases on human cells in vitro

Jaganjac, Morana and Prah, Iva Ozana and Čipak, Ana and Cindrić, Marina and Mrakovčić, Lidija and Tatzber, Franz and Ilinčić, Petar and Rukavina, Vinko and Spehar, Branka and Parlov Vuković, Jelena and Telen, Sanda and Uchida, Koji and Lulić, Zoran and Žarković, Neven (2012) Effects of bioreactive acrolein from automotive exhaust gases on human cells in vitro. = Effects of bioreactive acrolein from automotive exhaust gases on human cells in vitro. Environmental Toxicology, 27 (11). pp. 644-652. ISSN 1520-4081. Vrsta rada: ["eprint_fieldopt_article_type_article" not defined]. Kvartili JCR: Q1 (2012). Točan broj autora: 14.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/tox.206...

Abstract

Acrolein is a toxic unsaturated aldehyde and widespread environmental pollutant produced during lipid peroxidation and also by burning of tobacco or liquid fuels. Inhalation or dermal exposure to acrolein could be toxic to organisms. This very reactive aldehyde has a strong affinity for binding to proteins thus forming pathogenic protein-adducts. In the present study we have analyzed formation of bioreactive acrolein-protein adducts in bovine serum albumin solution exposed to exhaust gases of mineral diesel fuel and of mineral diesel fuel supplemented with different amounts of a novel diesel fuel additive denoted Ecodiesel (produced by a genuine procedure of recycling of plant oils used for food preparation). The effects of acrolein-protein adducts were tested on human microvascular endothelial cells and on human osteosarcoma cells that are sensitive to bioactivities of lipid peroxidation products. The results have shown a reduction of the bioreactive acrolein in exhaust gases when mineral diesel was supplemented with 5-20 Ecodiesel. Moreover, acrolein-protein adducts obtained from mineral diesel supplemented with Ecodiesel were less toxic than those obtained from mineral diesel alone. Thus, we assume that supplementing mineral diesel fuel with Ecodiesel would be of benefit for the use of renewable energy, for environment and for human health due to reduced environmental pollution with bioreactive acrolein. © 2011 Wiley Periodicals, Inc.

Item Type: Article (["eprint_fieldopt_article_type_article" not defined])
Keywords (Croatian): Acrolein; Automotive exhaust gas; Bovine serum albumins; Dermal exposure; Ecodiesel; Environmental pollutants; Environmental pollutions; Food oil; Food preparation; Human cells; Human health; Human microvascular endothelial cells; Human osteosarcoma cells; In-vitro; Lipid peroxidation; Plant oil; Renewable energies; Unsaturated aldehydes; Diesel fuels; Endothelial cells; Fuel additives; Herbicides; Lipids; Minerals; Oxidative stress; Proteins; Recycling; Vegetable oils; Aldehydes, acrolein; bovine serum albumin; diesel fuel; aldehyde; anthropogenic effect; automobile; diesel; exhaust emission; lipid; pollutant; renewable resource; toxic substance; toxicity; article; exhaust gas; human; human cell; in vitro study; lipid peroxidation; osteosarcoma; osteosarcoma cell; pollution; priority journal; recycling; renewable energy; Acrolein; Animals; Cattle; Cell Line; Environmental Pollutants; Gasoline; Humans; Lipid Peroxidation; Proteins; Serum Albumin; Bovine; Vehicle Emissions
Subjects: TECHNICAL SCIENCE
Divisions: 400 Department of IC Engines and Mechanical Handling Equipment > 410 Chair of IC Engines and Motor Vehicles
Indexed in Web of Science: Yes
Indexed in Current Contents: Yes
Quartiles: Q1 (2012)
Date Deposited: 30 Apr 2015 08:35
Last Modified: 01 Mar 2017 10:04
URI: http://repozitorij.fsb.hr/id/eprint/3911

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