On ultrasound-induced microbubble oscillation in a capillary blood vessel and its implications for the blood–brain barrier

Wiedemair, Wolfgang and Tuković, Željko and Jasak, Hrvoje and Poulikakos, Dimos and Kurtcuoglu, Vartan (2012) On ultrasound-induced microbubble oscillation in a capillary blood vessel and its implications for the blood–brain barrier. = On ultrasound-induced microbubble oscillation in a capillary blood vessel and its implications for the blood–brain barrier. Physics in Medicine and Biology, 57 (4). pp. 1019-1045. ISSN 0031-9155. Vrsta rada: ["eprint_fieldopt_article_type_article" not defined]. Kvartili JCR: Q1 (2012). Točan broj autora: 5.

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Official URL: http://iopscience.iop.org/article/10.1088/0031-915...

Abstract

The complex interaction between an ultrasound-driven microbubble and an enclosing capillary microvessel is investigated by means of a coupled, multi-domain numerical model using the finite volume formulation. This system is of interest in the study of transient bloodbrain barrier disruption (BBBD) for drug delivery applications. The compliant vessel structure is incorporated explicitly as a distinct domain described by a dedicated physical model. Red blood cells (RBCs) are taken into account as elastic solids in the blood plasma. We report the temporal and spatial development of transmural pressure (P tm) and wall shear stress (WSS) at the luminal endothelial interface, both of which are candidates for the yet unknown mediator of BBBD. The explicit introduction of RBCs shapes the P tmand WSS distributions and their derivatives markedly. While the peak values of these mechanical wall parameters are not affected considerably by the presence of RBCs, a pronounced increase in their spatial gradients is observed compared to a configuration with blood plasma alone. The novelty of our work lies in the explicit treatment of the vessel wall, and in the modelling of blood as a composite fluid, which we show to be relevant for the mechanical processes at the endothelium. © 2012 Institute of Physics and Engineering in Medicine.

Item Type: Article (["eprint_fieldopt_article_type_article" not defined])
Keywords (Croatian): Blood plasma; Blood-brain barrier; Capillary blood vessels; Complex interaction; Compliant vessels; Composite fluids; Drug delivery applications; Elastic solids; Explicit treatments; Finite-volume formulation; Mechanical process; Micro-bubble; Multi domains; Numerical models; Peak values; Physical model; Red blood cell; Spatial development; Spatial gradients; Transmural pressure; Vessel walls; Wall parameters; Wall shear stress; Blood; Drug delivery; Ultrasonics; Blood vessels; article; biomechanics; blood brain barrier; capillary; cytology; echography; endothelium cell; erythrocyte; human; metabolism; methodology; microbubble; time; ultrasound; Biomechanics; Blood-Brain Barrier; Capillaries; Endothelial Cells; Erythrocytes; Humans; Microbubbles; Time Factors; Ultrasonics
Subjects: TECHNICAL SCIENCE
Divisions: 500 Department of Energy, Power Engineering and Environment > 530 Chair of Turbomachinery
Indexed in Web of Science: Yes
Indexed in Current Contents: Yes
Quartiles: Q1 (2012)
Date Deposited: 27 Apr 2015 10:34
Last Modified: 30 Mar 2017 15:10
URI: http://repozitorij.fsb.hr/id/eprint/3970

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