A multilayered wall model of arterial growth and remodeling

Karšaj, Igor and Humphrey, Jay D. (2012) A multilayered wall model of arterial growth and remodeling. = A multilayered wall model of arterial growth and remodeling. Mechanics of Materials, 44. pp. 110-119. ISSN 0167-6636. Vrsta rada: ["eprint_fieldopt_article_type_article" not defined]. Kvartili JCR: Q1 (2012). Točan broj autora: 2.

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Abstract

Adaptations of large arteries to sustained alterations in hemodynamics that cause changes in both caliber and stiffness are increasingly recognized as important initiators or indicators of cardiovascular risk to high flow, low resistance organs such as the brain, heart, and kidney. There is, therefore, a pressing need to understand better the underlying causes of geometric and material adaptations by large arteries and the associated time courses. Although such information must ultimately come from well designed experiments, mathematical models will continue to play a vital role in the design of these experiments and their interpretation. In this paper, we present a new multilayered model of the time course of basilar artery growth and remodeling in response to sustained alterations in blood pressure and flow. We show, for example, that single- and multi-layered models consistently predict similar changes in caliber and wall thickness, but multilayered models provide additional insight into other important metrics such as the residual stress related opening angle and the axial prestress, both of which are fundamental to arterial homeostasis and responses to injury or insult. © 2011 Elsevier Ltd. All rights reserved.

Item Type:	Article (["eprint_fieldopt_article_type_article" not defined])
Keywords (Croatian):	Adaptation; Arterial growth; Basilar artery; Cardiovascular risk; Constrained mixture model; Designed experiments; Finite elasticity; High flow; Hypertension; Low resistance; Multi-layered; Opening angle; Pre-stress; Time course; Underlying cause; Wall model; Wall thickness; Blood pressure; Elasticity; Mathematical models; Residual stresses; Experiments
Subjects:	TECHNICAL SCIENCE
Divisions:	200 Department of Engineering Mechanics > 210 Chair of Mechanics and Strength of Materials
Indexed in Web of Science:	Yes
Indexed in Current Contents:	Yes
Quartiles:	Q1 (2012)
Date Deposited:	24 Apr 2015 12:57
Last Modified:	29 Nov 2016 07:28
URI:	http://repozitorij.fsb.hr/id/eprint/3978

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