Biochemomechanics of intraluminal thrombus in abdominal aortic aneurysms

Wilson, John S. and Virag, Lana and Di Achille, Paolo and Karšaj, Igor and Humphrey, Jay D. (2013) Biochemomechanics of intraluminal thrombus in abdominal aortic aneurysms. = Biochemomechanics of intraluminal thrombus in abdominal aortic aneurysms. Journal of Biomechanical Engineering, 135 (2). ISSN 0148-0731. Vrsta rada: ["eprint_fieldopt_article_type_article" not defined]. Kvartili JCR: Q2 (2013). Točan broj autora: 5.

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Abstract

Most computational models of abdominal aortic aneurysms address either the hemodynamics within the lesion or the mechanics of the wall. More recently, however, some models have appropriately begun to account for the evolving mechanics of the wall in response to the changing hemodynamic loads. Collectively, this large body of work has provided tremendous insight into this life-threatening condition and has provided important guidance for current research. Nevertheless, there has yet to be a comprehensive model that addresses the mechanobiology, biochemistry, and biomechanics of thrombus-laden abdominal aortic aneurysms. That is, there is a pressing need to include effects of the hemodynamics on both the development of the nearly ubiquitous intraluminal thrombus and the evolving mechanics of the wall, which depends in part on biochemical effects of the adjacent thrombus. Indeed, there is increasing evidence that intraluminal thrombus in abdominal aortic aneurysms is biologically active and should not be treated as homogeneous inert material. In this review paper, we bring together diverse findings from the literature to encourage next generation models that account for the biochemomechanics of growth and remodeling in patient-specific, thrombus-laden abdominal aortic aneurysms.

Item Type:	Article (["eprint_fieldopt_article_type_article" not defined])
Keywords (Croatian):	Abdominal aortic aneurysms; aorta; Biochemical effects; Comprehensive model; Computational model; Growth and remodeling; Hemodynamic load; Inert materials; inflammation; Intraluminal thrombus; Mechano-biology; Patient specific; proteases; Review papers; Biomechanics; Hemodynamics; Stress analysis; Blood vessels; matrix metalloproteinase; reparixin; abdominal aorta aneurysm; biomechanics; compression; computer assisted tomography; diffusion; fibrinolysis; hemodynamics; human; image analysis; intraluminal thrombus; medical literature; neutrophil; nonhuman; protein degradation; review; thermodynamics; thrombus; ultrastructure analysis and electron microscopy; abdominal aorta aneurysm; animal; biological model; biomechanics; mechanics; pathology; pathophysiology; thrombosis; Animals; Aortic Aneurysm; Abdominal; Biomechanics; Humans; Mechanical Processes; Models; Biological; Thrombosis
Subjects:	TECHNICAL SCIENCE > Mechanical Engineering
Divisions:	200 Department of Engineering Mechanics > 210 Chair of Mechanics and Strength of Materials
Indexed in Web of Science:	Yes
Indexed in Current Contents:	Yes
Quartiles:	Q2 (2013)
Date Deposited:	06 May 2015 10:44
Last Modified:	29 Nov 2016 07:50
URI:	http://repozitorij.fsb.hr/id/eprint/4069

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