Implementation of Thrombus-laden Abdominal Aortic Aneurysms into Finite Element Code

Virag, Lana and Vindiš, Vedran and Sorić, Jurica and Karšaj, Igor (2015) Implementation of Thrombus-laden Abdominal Aortic Aneurysms into Finite Element Code. = Implementation of Thrombus-laden Abdominal Aortic Aneurysms into Finite Element Code. In: 8th International Congress of Croatian Society of Mechanics, 29.09.-02.10.2015., Opatija, Hrvatska.

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Official URL: http://bib.irb.hr/prikazi-rad?&rad=787945

Abstract

Abdominal aortic aneurysm (AAA) is a localized dilatation of the abdominal aorta characterized by formation of intraluminal thrombus (ILT). These thrombi biologically and mechanically influence growth and remodeling (G&R) of AAAs, and therefore, they should not be treated as homogenous inert material. Yet, hitherto developed computational growth and remodeling models have neglected complex biochemomechanical influence of the thrombus on the evolution of the disease. Due to significant loss of functional elastin and smooth muscle, collagen remains the principal load-bearing constituent in the aneurysmal wall, and therefore its turnover and mechanical properties were believed to have a critical role in the natural history of the lesion. Yet, our comprehensive growth and remodeling model of thrombus-laden AAAs applied to cylindrical geometry, suggested collagen properties, albeit important, are not the only ones to determine clinical outcome of AAA enlargement. Additionally, the computational results showed that biochemical and biomechanical properties of ILT have a great influence on AAA growth pattern, and are a likely cause of discontinuous growth. Therefore, in order to confirm these hypotheses, there is a need to improve modeling of collagen fibers and to use more realistic geometries, i.e. implement model into finite element code.

Item Type: Conference or Workshop Item (Lecture)
Keywords (Croatian): thrombus, aneurysm, G&R
Subjects: TECHNICAL SCIENCE > Mechanical Engineering
Divisions: 200 Department of Engineering Mechanics > 210 Chair of Mechanics and Strength of Materials
Indexed in Web of Science: No
Indexed in Current Contents: No
Date Deposited: 22 Apr 2016 11:03
Last Modified: 29 Nov 2016 08:25
URI: http://repozitorij.fsb.hr/id/eprint/5753

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